The Role of Microglia in Neuroinflammation
Microglia have been considered key players in brain injury, as well as the development of neuroinflammation and neurodegeneration. Upon stimulation, activated microglia adopt an ameboid shape that renders them capable of phagocytosis and release of pro-inflammatory cytokines and free radicals. Mast cells communicate with microglia (Figure 7) leading to their activation and contributing to neuroinflammation….