Mast cells are important effector cells in IgE-mediated allergic reactions, but also in immunity [1, 2] and inflam- matory processes [3] due to their ability to secrete numer- ous vasoactive molecules and cytokines in response to a variety of stimuli. For instance, mast cells can secrete his- tamine, interleukin (IL)-6, IL-8, platelet-activating factor (PAF), tumor necrosis factor (TNF), tryptase and vascu- lar endothelial growth factor (VEGF) [4]. IL-6 participates in inflammation and acute-phase reactions [5], while IL-8 is a potent neutrophil chemotactic molecule [6], and VEGF also has vasodilatory actions [7]. In view of such findings, mast cells are now recognized to have a more critical role in diseases that may also involve in- flammation, such as in asthma [8], but also in skin dis- eases [9].
