Interstitial cystitis, a painful inflammatory bladder disease that occurs primarily in women, is characterized by bladder/pelvic pain, urgency, frequency and variable inflammation in the absence of urinary tract infection.1 There is no curative treatment for IC.2 A number of immunomodulators have been tested or proposed for IC.3 The 2 main theories of IC pathophysiology are some defect in the bladder protective glycosaminoglycan layer and an increased number of activated bladder mast cells,4 which is the only pathological finding that correlates with nocturia.5
