Dietary supplements for arthritis and otherinflammatory conditions: key role of mast cells and benefitof combining anti-inflammatory and proteoglycan products
T. C. Theoharides
Eur J Inflamm 2003; 1:1-8
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Arthritis is estimated to affect over 30% of all adults and all the available drugs add considerablemorbidity and mortality of their own. A recent therapeutic approach targets the mast cells that arecurrently considered critical in a variety of inflammatory diseases, especially arthritis. Mast cells could beactivated by many immune and neural triggers, as well as by many food substances and drugs leading tosecretion of numerous vasoactive and inflammatory molecules. Recent studies have shown that mast cellscan be inhibited by certain naturally occurring flavonoids, such as quercetin, and the sulfated proteoglycanchondroitin sulfate. Glucosamine and chondroitin are present in many dietary supplements, but neither thesource nor the purity of the active substances is listed; moreover, these formulations do not permitsufficient absorption, due to the high molecular weight and negative charge. Moreover, a common sourceof chondroitin sulfate is cow trachea with the risk of spongioform encephalopathy (mad cow disease). A newseries of dietary supplements (Algonot-Plus®) are based on published scientific evidence and combinequercetin, glucosamine sulfate and chondroitin sulfate of high purity in formulations that include kernelolive oil to increase absorption of the inhibitory substances. (continued please downlaod the pdf for the full article)
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